{"id":1108,"date":"2023-01-16T19:23:00","date_gmt":"2023-01-16T19:23:00","guid":{"rendered":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/?p=1108"},"modified":"2023-01-18T20:05:28","modified_gmt":"2023-01-18T20:05:28","slug":"why-are-the-okazaki-fragments-important","status":"publish","type":"post","link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/why-are-the-okazaki-fragments-important\/","title":{"rendered":"Why are the Okazaki fragments important?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">By Lina Jeffery<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">What exactly are Okazaki fragments and why are they important in our cells? They actually play a fundamental role in the replication of our DNA, as they efficiently and effectively aid in lagging strand replication. Beyond that, their discovery in 1966 is attributed to a unique team with an intriguing story.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-mivideo wp-block-embed-mivideo\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Bio305 Video Project: What are Okazaki Fragments?\" id=\"kaltura_player\" src=\"https:\/\/cdnapisec.kaltura.com\/p\/1038472\/sp\/103847200\/embedIframeJs\/uiconf_id\/46145191\/partner_id\/1038472?iframeembed=true&#038;playerId=kaltura_player&#038;entry_id=1_rzis57ax&#038;flashvars[leadWithHTML5]=true&#038;flashvars[streamerType]=auto&#038;flashvars[localizationCode]=en_US&#038;flashvars[sideBarContainer.plugin]=true&#038;flashvars[sideBarContainer.position]=left&#038;flashvars[sideBarContainer.clickToClose]=true&#038;flashvars[chapters.plugin]=true&#038;flashvars[chapters.layout]=vertical&#038;flashvars[chapters.thumbnailRotator]=false&#038;flashvars[streamSelector.plugin]=true&#038;flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&#038;flashvars[dualScreen.plugin]=true&#038;flashvars[hotspots.plugin]=1&#038;flashvars[Kaltura.addCrossoriginToIframe]=true&#038;wid=1_f1m8e4iv\" width=\"608\" height=\"402\" allowfullscreen webkitallowfullscreen allow=\"autoplay *; fullscreen *; encrypted-media *\" sandbox=\"allow-downloads allow-forms allow-same-origin allow-scripts allow-top-navigation allow-pointer-lock allow-popups allow-modals allow-orientation-lock allow-popups-to-escape-sandbox allow-presentation allow-top-navigation-by-user-activation\" frameborder=\"0\" mozAllowFullScreen><\/iframe>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>What exactly are Okazaki fragments and why are they important in our cells? They actually play a fundamental role in the replication of our DNA, as they efficiently and effectively aid in lagging strand replication. Beyond that, their discovery in 1966 is attributed to a unique team with an intriguing story. <a class=\"more-link\" href=\"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/why-are-the-okazaki-fragments-important\/\"><\/a><\/p>\n","protected":false},"author":4336,"featured_media":1113,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[63],"tags":[],"class_list":["post-1108","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-replication"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=480%2C300&ssl=1","uagb_featured_image_src":{"full":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=480%2C300&ssl=1",480,300,false],"thumbnail":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=150%2C150&ssl=1",150,150,true],"medium":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=300%2C188&ssl=1",300,188,true],"medium_large":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=480%2C300&ssl=1",480,300,true],"large":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=480%2C300&ssl=1",480,300,true],"1536x1536":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=480%2C300&ssl=1",480,300,true],"2048x2048":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?fit=480%2C300&ssl=1",480,300,true],"catchresponsive-slider":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=480%2C300&ssl=1",480,300,true],"catchresponsive-featured-content":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=350%2C197&ssl=1",350,197,true],"catchresponsive-hero":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=480%2C297&ssl=1",480,297,true],"catchresponsive-featured":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=480%2C300&ssl=1",480,300,true],"catchresponsive-square":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=200%2C200&ssl=1",200,200,true],"catchresponsive-sm-square":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=100%2C100&ssl=1",100,100,true],"catchresponsive-stats":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Okazaki_fragments-1.png?resize=40%2C40&ssl=1",40,40,true]},"uagb_author_info":{"display_name":"wierzbic","author_link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/author\/wierzbic\/"},"uagb_comment_info":0,"uagb_excerpt":"What exactly are Okazaki fragments and why are they important in our cells? They actually play a fundamental role in the replication of our DNA, as they efficiently and effectively aid in lagging strand replication. Beyond that, their discovery in 1966 is attributed to a unique team with an intriguing story.","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1124,"url":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/how-are-chromosome-ends-maintained\/","url_meta":{"origin":1108,"position":0},"title":"How are chromosome ends maintained?","author":"wierzbic","date":"January 17, 2023","format":false,"excerpt":"This video discusses the significance of telomeres and telomerase. Specifically, it summarizes how they work, why they are important, and when problems can arise, especially in cancer. It also discusses their association with aging.","rel":"","context":"In &quot;DNA replication&quot;","block_context":{"text":"DNA replication","link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/category\/replication\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Telomeres.png?fit=480%2C300&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":831,"url":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/the-importance-of-telomeres-and-telomerase\/","url_meta":{"origin":1108,"position":1},"title":"The Importance of Telomeres and Telomerase","author":"hilaryar","date":"January 6, 2023","format":false,"excerpt":"https:\/\/www.mivideo.it.umich.edu\/id\/1_e7w34uaj?width=608&height=402&playerId=46145191 This video discusses the significance of telomeres and telomerase. Specifically, it summarizes how they work, why they are important, and when problems can arise, especially in cancer. It also discusses their association with aging.","rel":"","context":"In &quot;Structure and Function of Nucleic Acids&quot;","block_context":{"text":"Structure and Function of Nucleic Acids","link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/category\/the-chemistry-of-atcg\/structure-and-function-of-nucleic-acids\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts\/1108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/users\/4336"}],"replies":[{"embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/comments?post=1108"}],"version-history":[{"count":3,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts\/1108\/revisions"}],"predecessor-version":[{"id":1228,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts\/1108\/revisions\/1228"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/media\/1113"}],"wp:attachment":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/media?parent=1108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/categories?post=1108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/tags?post=1108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}