{"id":1157,"date":"2023-01-17T16:23:49","date_gmt":"2023-01-17T16:23:49","guid":{"rendered":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/?p=1157"},"modified":"2023-01-18T20:01:39","modified_gmt":"2023-01-18T20:01:39","slug":"what-is-microrna-and-how-does-it-work-2","status":"publish","type":"post","link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/what-is-microrna-and-how-does-it-work-2\/","title":{"rendered":"What is microRNA and how does it work?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">By Mira Bhandari<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">microRNAs are a family of small, non-coding RNA molecules that have garnered increasing attention in the last 30 years. Their functionality as post-transcriptional off-switches make them important regulators of gene expression. This ability also suggests that microRNA therapies may have exciting clinical promise.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-mivideo wp-block-embed-mivideo\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"microRNA: Transcriptional Off-Switch\" id=\"kaltura_player\" src=\"https:\/\/cdnapisec.kaltura.com\/p\/1038472\/sp\/103847200\/embedIframeJs\/uiconf_id\/46145191\/partner_id\/1038472?iframeembed=true&#038;playerId=kaltura_player&#038;entry_id=1_2x74xkk6&#038;flashvars[leadWithHTML5]=true&#038;flashvars[streamerType]=auto&#038;flashvars[localizationCode]=en_US&#038;flashvars[sideBarContainer.plugin]=true&#038;flashvars[sideBarContainer.position]=left&#038;flashvars[sideBarContainer.clickToClose]=true&#038;flashvars[chapters.plugin]=true&#038;flashvars[chapters.layout]=vertical&#038;flashvars[chapters.thumbnailRotator]=false&#038;flashvars[streamSelector.plugin]=true&#038;flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&#038;flashvars[dualScreen.plugin]=true&#038;flashvars[hotspots.plugin]=1&#038;flashvars[Kaltura.addCrossoriginToIframe]=true&#038;wid=1_8of6lbmv\" width=\"608\" height=\"402\" allowfullscreen webkitallowfullscreen allow=\"autoplay *; fullscreen *; encrypted-media *\" sandbox=\"allow-downloads allow-forms allow-same-origin allow-scripts allow-top-navigation allow-pointer-lock allow-popups allow-modals allow-orientation-lock allow-popups-to-escape-sandbox allow-presentation allow-top-navigation-by-user-activation\" frameborder=\"0\" mozAllowFullScreen><\/iframe>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>microRNAs are a family of small, non-coding RNA molecules that have garnered increasing attention in the last 30 years. Their functionality as post-transcriptional off-switches make them important regulators of gene expression. This ability also suggests that microRNA therapies may have exciting clinical promise. <a class=\"more-link\" href=\"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/what-is-microrna-and-how-does-it-work-2\/\"><\/a><\/p>\n","protected":false},"author":4336,"featured_media":1155,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[66],"tags":[],"class_list":["post-1157","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-regulation"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=480%2C300&ssl=1","uagb_featured_image_src":{"full":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=480%2C300&ssl=1",480,300,false],"thumbnail":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=150%2C150&ssl=1",150,150,true],"medium":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=300%2C188&ssl=1",300,188,true],"medium_large":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=480%2C300&ssl=1",480,300,true],"large":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=480%2C300&ssl=1",480,300,true],"1536x1536":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=480%2C300&ssl=1",480,300,true],"2048x2048":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?fit=480%2C300&ssl=1",480,300,true],"catchresponsive-slider":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=480%2C300&ssl=1",480,300,true],"catchresponsive-featured-content":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=350%2C197&ssl=1",350,197,true],"catchresponsive-hero":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=480%2C297&ssl=1",480,297,true],"catchresponsive-featured":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=480%2C300&ssl=1",480,300,true],"catchresponsive-square":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=200%2C200&ssl=1",200,200,true],"catchresponsive-sm-square":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=100%2C100&ssl=1",100,100,true],"catchresponsive-stats":["https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA.png?resize=40%2C40&ssl=1",40,40,true]},"uagb_author_info":{"display_name":"wierzbic","author_link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/author\/wierzbic\/"},"uagb_comment_info":0,"uagb_excerpt":"microRNAs are a family of small, non-coding RNA molecules that have garnered increasing attention in the last 30 years. Their functionality as post-transcriptional off-switches make them important regulators of gene expression. This ability also suggests that microRNA therapies may have exciting clinical promise.","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1152,"url":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/what-is-microrna-and-how-does-it-work\/","url_meta":{"origin":1157,"position":0},"title":"What is microRNA and how does it work?","author":"wierzbic","date":"January 17, 2023","format":false,"excerpt":"This video introduces the production and purpose of miRNA. It discusses the functions of proteins including Drosha, Dicer, and RISC. The produced miRNA functions in posttranscriptional regulation by blocking translation or cutting mRNA to silence gene expression.","rel":"","context":"In &quot;Gene regulation&quot;","block_context":{"text":"Gene regulation","link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/category\/regulation\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/miRNA_1.png?fit=479%2C300&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":1132,"url":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/what-is-the-difference-between-dna-and-rna\/","url_meta":{"origin":1157,"position":1},"title":"What is the difference between DNA and RNA?","author":"wierzbic","date":"January 17, 2023","format":"video","excerpt":"The central dogma of biology hints that DNA is for long-term storage of information and RNA is for quickly making lots of copies of a gene when needed for expression. But what biochemical differences exist between DNA and RNA to make these roles happen?","rel":"","context":"In &quot;Nucleic Acids and their properties&quot;","block_context":{"text":"Nucleic Acids and their properties","link":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/category\/dna\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/courses.lsa.umich.edu\/genetics-simplified\/wp-content\/uploads\/sites\/122\/2023\/01\/Nucleic_acids.png?fit=480%2C300&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts\/1157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/users\/4336"}],"replies":[{"embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/comments?post=1157"}],"version-history":[{"count":2,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts\/1157\/revisions"}],"predecessor-version":[{"id":1219,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/posts\/1157\/revisions\/1219"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/media\/1155"}],"wp:attachment":[{"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/media?parent=1157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/categories?post=1157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/courses.lsa.umich.edu\/genetics-simplified\/wp-json\/wp\/v2\/tags?post=1157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}