Research Mentor(s): Vikas Kotagal, Assistant Professor
Research Mentor School/College/Department: Neurology, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 6 (4pm-4:50pm)
Breakout Room: Room 12
Idiopathic Rapid Eye Movement Sleep Disorder (iRBD) is a disorder characterized by dream re-enactment. RBD is referred to as idiopathic when it occurs in isolation. A majority of iRBD patients will go on to receive a diagnosis of an a-synucleinopathy, a family of neurodegenerative disorders including Parkinson’s and Dementia with Lewy Bodies (DLB) . In clinical settings, iRBD is likely to be diagnosed by a variety of medical providers including specialists in Neurology, Psychiatry, and Primary Care. iRBD patients often have 10-15 years in between the onset of iRBD and the onset of a neurodegenerative disorder, leaving a considerable length of time in which to intervene with therapeutic approaches. The problem is that as of yet, we are not sure in which clinical settings patients are receiving their diagnoses of iRBD. Our project aims to bridge this knowledge gap, which currently prevents us from recruiting iRBD patients into clinical trials aimed at preventing a-synucleinopathies such as Parkinson’s and DLB. In order to gather our data, we have conducted a retrospective chart review of UM medical records for relevant patients. We hope to gain a clear picture of where patients are receiving their iRBD diagnoses, in hopes of further research in the future. References  McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz JB, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P (2020) Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology 94, 743-755.