Explaining the variability in C. elegans wild-type longevity – UROP Spring Symposium 2021

Explaining the variability in C. elegans wild-type longevity

Richard Sukpraphrute


Pronouns: he/him/his

Research Mentor(s): Matthias Truttmann, Assistant Professor
Research Mentor School/College/Department: Molecular & Integrative Physiology, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 6 (4pm-4:50pm)
Breakout Room: Room 9
Presenter: 1

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Aging is a dynamic and complicated process, and although it affects every organism, the topic remains poorly understood. The topic is also very hard to study on humans because of the time requirements. To circumvent this limitation, scientists utilize model organisms and study cellular physiology to determine the molecular pathology of aging. A common model organism for aging experiments is the Caenorhabditis elegans (the roundworm) because it is small, inexpensive, has a short lifespan, and its developmental anatomy has been very well characterized–making it a perfect model organism for studying aging. The N2 strain is used as a control and is standard for laboratory experiments. However, it has become apparent after experience in published literature that there exists an inherently variability in the N2 C. elegans lifespans. In order to address this issue, approximately 1,000 experiments extracted from primary published literature were analyzed from around the and data was extracted from the N2 wild type C. elegans. We then performed a metanalysis of our primary data based on a set of conditions explicitly extracted from these experiments. While data collection is ongoing, we aim to identify seemingly “soft” conditions to create standard models of lifespans of C. elegans under specific conditions to aid other researchers with their aging experiments with C. elegans.

Authors: Richard Sukpraphrute
Research Method: Library/Archival/Internet Research

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