NeuroInsight: A novel toolbox to study the mechanisms of epileptic seizures – UROP Spring Symposium 2021

NeuroInsight: A novel toolbox to study the mechanisms of epileptic seizures

Daniel Najarian


Research Mentor(s): Omar Ahmed, Assistant Professor
Research Mentor School/College/Department: Psychology, College of Literature, Science, and the Arts
Presentation Date: Thursday, April 22, 2021
Session: Session 3 (1pm-1:50pm)
Breakout Room: Room 10
Presenter: 3

Event Link


Millions of Americans suffer from epileptic seizures that result in a temporary loss of consciousness. The majority of our understanding of neural dynamics during seizures is based on extracellular recordings, with intracellular neuronal recordings not yet possible in patients. Here, we create a toolbox – called NeuroInsight – that can allow for the decoding of estimated intracellular potentials based only on extracellular single neuron recordings. NeuroInsight’s algorithms can approximate the intracellular membrane potential of neurons and identify periods of excessive depolarization that may correlate with increased seizure likelihood. We streamline the analysis process by including multiple built in visualization tools. Furthermore, the isolation quality of sorted single units can be evaluated with two included metrics. This novel toolbox has the promise to be an important resource for both clinicians and researchers studying the mechanisms of multiple forms of epilepsy.

Authors: Daniel Najarian, Danny Siu, Omar Ahmed
Research Method: Laboratory Research with Animals

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