Ontology-based machine learning towards COVID-19 drug understanding – UROP Spring Symposium 2021

Ontology-based machine learning towards COVID-19 drug understanding

Eray Sabuncu


Pronouns: he/him

Research Mentor(s): Yongqun He, Associate Professor
Research Mentor School/College/Department: Lab Animal Medicine, Microbiology and Immunology, & Bioinformatics, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 1 (10am-10:50am)
Breakout Room: Room 17
Presenter: 4

Event Link


The pandemic caused by COVID 19 marked its one-year anniversary on March 12, 2021. Since last spring, millions have been victims of this terrible disease and millions have been infected across the globe. In the United States alone, there have been almost 30 million cases, and over 500 thousand people have passed away. Vaccines have been manufactured and distributed around the globe, however, officials predict that COVID 19 will never be fully eradicated, similar to the flu. That is why the objective of the COVID-19 Bioinformatics research project is to determine a drug or a cocktail of drugs using COVID-19 virology data and machine learning that can potentially provide treatment. The process of implementing the algorithms began with feeding data into an algorithm titled OpA2Vec that transformed ontology-based axioms into high dimensional vector representations using cosine similarities. These high-dimensional vectors will be compressed into two dimensions by running them through a t-distributed stochastic neighbor embedding (t-SNE) analysis in order to graph them on two dimensions. The vectors represent how effectively different drugs will react with the different target proteins of COVID19. The graph will help determine clusters or patterns to develop a proof of concept and a potential hypothesis for future experimental verification. A linear neural network modeling is also being implemented. The results will be able to demonstrate a potential drug design for the COVID19 virus that has completely transformed the world as we know it today. Our results will provide a proof of concept to potentially support the experimental verification of our theoretical findings.

Authors: Eray Sabuncu, Aster Qian, Anthony Huffman, Yongqun Oliver He
Research Method: Computer Programming

lsa logoum logo