Prefrontal-Hippocampal Interactions Supporting Memory Consolidation During Sleep – UROP Spring Symposium 2021

Prefrontal-Hippocampal Interactions Supporting Memory Consolidation During Sleep

Joseph Haddad


Pronouns: he/him

Research Mentor(s): Nathaniel Kinsky, Postdoctoral Researcher
Research Mentor School/College/Department: Anesthesiology, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 4 (2pm-2:50pm)
Breakout Room: Room 14
Presenter: 6

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In this research I will explore how short term memories are supported by the hippocampus and prefrontal cortex. For this project, I trained a cohort of rats on a trace fear conditioning task to evaluate hippocampal-dependent learning and memory. Trace fear conditioning is a hippocampus-dependent learning task that obligates the cohort of rats used to associate an auditory conditioned stimulus (CS) and a minor shock used as the unconditioned stimulus (US) that are separated by an empty trace interval time period. I am currently analyzing the behavior of this cohort through characteristics such as ultrasonic vocalizations (USVs), freezing, and other behavioral traits. With this preliminary data, this project will exploit the effective methods of chronic electrophysiological and calcium imaging recordings in the future. These techniques will be used to probe how sleep influences long-term changes in cortical neurons following learning of a trace fear-conditioning memory task.

Authors: Joseph Haddad, Nathaniel Kinsky
Research Method: Laboratory Research

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