Anushka Dalvi
Pronouns: she/her/hers
Research Mentor(s): Vincent Chen, Clinical lecturer
Research Mentor School/College/Department: Internal Medicine, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 1 (10am-10:50am)
Breakout Room: Room 10
Presenter: 5
Abstract
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in the liver due to causes unrelated to excessive alcohol consumption. Around 25% of the global population is affected by NAFLD, with some countries having even higher rates.[1] However, most people with this condition are just suggested to change their lifestyle.[2] Often associated with these underlying causes are cardiovascular disease (CVD) and high cholesterol levels, which the class of drugs known as statins are often prescribed to help treat. Statins have been shown to lead to some liver injury and therefore they have not been a popular medication physicians consider for NAFLD.[3] Thus, the aim of this study will be to explore the impact of statins on treating the progression of NAFLD. While some studies have been performed on the effects of statins on liver disease associated with varying causes,[4] it is not well-known what effect these medications have on the progression of NAFLD. Some have suggested that there is a beneficial effect in reducing the time it takes the disease to progress[5,6] and generally improving liver blood tests,[7] but there are not many systematic reviews synthesizing all recent data. Our goal is to conduct an updated systematic review and meta-analysis of the current literature investigating the effects of statins on NAFLD to determine the consensus on whether these medications do have a beneficial effect in disease progression. To investigate this relationship, we used Cochrane Library, PubMed, and EMBASE to gather all the references, utilizing the Boolean search method to collect the past research studies using all keywords relating to NAFLD and statins. The relevant, qualified studies were then compiled into EndNote X9, and Microsoft Excel and R statistical software were used to conduct a formal meta-analysis (i.e., inclusion of forest plot, funnel plot, etc.). The data is expected to show that statins do help improve the condition of NAFLD patients due to decreasing the build-up of fat and improving NAFLD test scores. The implications of this study will allow for physicians to more easily reject or approve of the use of statins in NAFLD treatment.
Authors: Anushka Dalvi
Research Method: Clinical Research
