Annika Tekumulla
Pronouns: she/her
Research Mentor(s): Salim Hayek, Assistant Professor – Internal Medicine
Research Mentor School/College/Department: Internal Medicine – Cardiology, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 2 (11am – 11:50am)
Breakout Room: Room 11
Presenter: 5
Abstract
The novel coronavirus SARS-CoV-2 (COVID-19) is rapidly spreading around the world with 119,220,681 confirmed cases as of March 14, 2021. As a result of COVID-19, a significant proportion of patients experienced reduced oxygenation and subsequent hypoxia which have prompted fluctuations in molecular and cell signaling pathways. Recent COVID-19 studies indicate that there is a high cumulative incidence of venous thromboembolism (VTE) in critically ill COVID-19 patients. Due to this prevalence, thrombosis prophylaxis is suggested as the standard of care for VTEs in patients. Thrombosis prophylaxis is instituted if the risk of thrombotic complications is high. However, there have been instances where VTE developed despite the use of thromboprophylaxis. These results highlight that VTE prophylaxis treatment may not be adequate for severe COVID-19 cases. This study will investigate the efficacy of therapeutic anticoagulation after deep vein thrombosis or pulmonary embolism is identified in COVID19 patients in Intensive Care. Data mining approaches and manual chart review were used to retrospectively collect granular clinical data for 1065 adult patients (=18 years) with severe COVID-19 admitted to the University of Michigan. We hope to see a negative association between the administration of therapeutic anticoagulation and the proportions of patients who experienced DVT during their hospital admission versus patients who did not.
Authors: Annika Tekumulla , Elizabeth Anderson, Pennelope Blakely Kunkle, Salim Hayek
Research Method: Data Collection and Analysis
