Sophie Vince
Pronouns: she/her
Research Mentor(s): Yuji Mishina
Co-Presenter:
Research Mentor School/College/Department: Biological and Material Sciences / Dentistry
Presentation Date: April 20
Presentation Type: Poster
Session: Session 4 – 2:40pm – 3:30 pm
Room: League Ballroom
Authors: Sophie Vince, Maiko Omi, Yuji Mishina
Presenter: 31
Abstract
It is hypothesized that mechanical stress induced by mastication plays a role in the different responses of BMP signaling in jawbones and long bones. The goal of this project is to compare features of the jawbone and long bones in order to identify the role of bone morphogenetic proteins (BMPs) signaling in jawbone remodeling and to understand how mechanical stress affects BMP signaling in long bones and jawbones. Cells have been harvested from both long bones and jawbones in BMP receptor mutant mice (conditional knockout) as well as constitutively activated mice. Use of the Flexcell tension system to analyze mechanical strain will help us to understand how mechanical stress, as well as BMP signaling, affects the function of bone cells. This study will provide insight into the interaction between BMP signaling in bone remodeling and mechanical stress which may play a valuable role in the development of new treatments for jawbone diseases.
Biomedical Sciences, Interdisciplinary, Natural/Life Sciences
