Modulation of Pulmonary Host Defenses in Pathogenesis of Chronic Infections – UROP Spring Symposium 2022

Modulation of Pulmonary Host Defenses in Pathogenesis of Chronic Infections

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Rachel Bareis

Pronouns: she, her, hers

Research Mentor(s): Michal Olszewski
Co-Presenter:
Research Mentor School/College/Department: Internal Medicine, Pulmonary and Critical Care Medicine / Medicine
Presentation Date: April 20
Presentation Type: Poster
Session: Session 4 – 2:40pm – 3:30 pm
Room: League Ballroom
Authors: Rachel Bareis, Mihal Olszewski, Kristie Goughenour
Presenter: 74

Abstract

Cryptococcus has been proven to be successfully treated with T-Cell depletion, therefore, we looked to further this investigation by depleting two different t-cells, CD-4 T-cells and CD-8 T-cells. After running survival tests, however, it was found that the CD-4 T-cell depleted mice survived longer, however, the CD-8 T-cell depleted mice were not. To further this investigation we plan on running more survival tests of the CD-8 T-cell depleted mice and run PCR, flow cytommetry, and CFU’s to find the reason for this difference in treatment success.

Presentation link

Biomedical Sciences, Interdisciplinary, Natural/Life Sciences

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