Wenxin Guo
Pronouns: She/Her
Research Mentor(s): Yongqun He
Co-Presenter:
Research Mentor School/College/Department: Lab Animal Medicine, Microbiology and Immunology, & Bioinformatics / Medicine
Presentation Date: April 20
Presentation Type: Oral5
Session: Session 4 – 2:40pm – 3:30 pm
Room: Breakout room 1
Authors: Wenxin Guo, Yongqun He
Presenter: 4
Abstract
COVID-19 vaccines have been developed to mitigate the wide-spread infection of the virus SARS-CoV-2; however, adverse events associated with these vaccines might exist. It is worth investigating the adverse events of COVID-19 vaccines, which are closely related to the safety of these vaccines, since more and more people in the United States have been vaccinated. In this study, three FDA-authorized vaccines, Pfizer-BioNTech COVID-19, Moderna COVID-19, and Johnson & Johnson’s COVID-19, were analyzed. First of all, literature mining of similar studies in PubMed were conducted. After all data were collected from the Vaccine Adverse Events Reporting System (VAERS) of the Centers for Disease Control and Prevention (CDC) and were processed as of 12/31/2021, statistical analysis of the adverse events was conducted. Three statistical methods, including the case number reporting, Proportional Reporting Ratio (PRR), and the Chi-square test statistic were used. After all results were calculated, we also focused on the analysis of the effects of different ages, doses, and sexes on the Myocarditis adverse event after COVID-19 vaccination. Our results showed that for the Myocarditis adverse event in Pfizer vaccine-administered population, statistically significant results are found in many subgroups as well as the overall evaluation. Besides, the Janssen vaccine might be related to thrombosis. The study suggests the associations, but the adverse events are rare, affirming the safety of COVID-19 vaccines.
Engineering, Interdisciplinary, Natural/Life Sciences
