Julian Meza
Pronouns: He/Him/His
Research Mentor(s): Anna Mathew
Co-Presenter:
Research Mentor School/College/Department: Internal Medicine/ Nephrology / Medicine
Presentation Date: April 20
Presentation Type: Oral10RS
Session: Session 5 – 3:40pm – 4:30 pm
Room: Vandenberg
Authors: Julian Meza, Biaoxin Chai, Anna Mathew
Presenter: 3
Abstract
Cardiovascular Disease (CVD) remains a leading cause of mortality for patients with Chronic Kidney Disease (CKD). Many non-traditional risk factors like oxidative stress and inflammation play a role in the exaggerated risk of CVD in patients with CKD. Tryptophan Catabolism via the Kynurenine pathway is linked to incident CV events in patients with CKD; However, the role of tryptophan catabolite, 3-hydroxyanthranilic acid (3-HAA) in decreasing the inflammation related to CKD associated CVD is not well studied. We treated mice with decreased renal function with intraperitoneal 3-HAA for 16 weeks and found that the atherosclerosis content is decreased compared to control mice. Our findings confirm our hypothesis that 3-HAA reverses the inflammation and CVD associated with CKD.
Biomedical Sciences, Interdisciplinary, Natural/Life Sciences
