Yumeng Guo
Pronouns: she/her/hers
Research Mentor(s): Mohamad Tiba
Research Mentor School/College/Department: Emergency Medicine / Medicine
Program: UROP
Session: Session 6 (3:40pm – 4:30pm)
Authors: Claire Guo, Matthew Truwit, Matthew Ronfeldt
Abstract
Introduction: The monitoring of the blood flow and oxygenation status is very important in developing treatment plans in critical care, and technologies that can provide precise measurements are needed for better patient care and outcomes. The current measurement of venous oxygen saturation (SvO2) however does not reflect the oxygenation status at a microvascular level. The purpose of this study is to validate the usage of technologies such as piezoelectric sensors that might be able to fill this gap using swine models of traumatic brain injury (TBI). Methods: Animals were anesthetized and instrumented for measurements of blood pressure, intracranial pressure, and carotid artery blood flow. Several burr holes were drilled into the skull to measure Laser Doppler flow as well as the insertion of the piezo sensor that would allow later measurements of intracranial pressure and cerebral blood flow. Animals were subjected to several maneuvers to manipulate hemodynamics and change oxygenation and blood flow. The piezoelectric signal will be processed and compared to intracranial pressure and cerebral blood flow. Results: The study is still in the process of collecting and analyzing data. The final results can provide information on the direction of medical device development, and new precision diagnostic and prognostic devices for the treatment of TBI patients. A better understanding of the effects of cerebral blood flow on TBI can also be achieved and adding more factors to consider when providing care.
