Phoebe Paredez
Pronouns: she/her
Research Mentor(s): Abdullah Saeed
Research Mentor School/College/Department: Internal Medici/Hematology-Oncology / Medicine
Program:
Authors:
Session: Session 7: 4:40 pm – 5:30 pm
Poster: 6
Abstract
The immune system plays a critical role in lung cancer. The global effect of lung cancer is substantial since it ranks first among cancers in terms of mortality and ranks second in terms of the frequency of cancer diagnoses. Morphologically and immunohistochemically, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) are the leading lung cancer types. SCLC has a worse prognosis, whereas NSCLC, which accounts for 83% of cases, is categorized as adenocarcinoma (ADC), squamous cell carcinoma (SqCC), and other minority subgroups such as large-cell carcinoma. Tumor cells often dampen immunity through immune evasion by recruiting immunosuppressive immune cells in the Tumor microenvironment (TME). Here, we focus on characterizing the immune landscape in the ALK+ lung cancer mice model and immunosuppression. We employed multi-color flow cytometry to immunophenotype the expression of immune markers to determine immune responses. Regulatory T-cells (Tregs) are critical in immunosuppression and tumor advancement. We used flow cytometry antibody panel, i.e., CD3, CD4, CD25, and FOXP3, to characterize the frequency of Tregs in the spleen of tumor-bearing mice. Moreover, the study will further shed light on potential future therapeutic approaches in lung cancer and the immune system and their potential clinical applications to improve human health.
