Morgan Morris
Research Mentor(s): Tina Lasisi
Mentor Department: Anthropology
Authors: Morgan Morris, Paloma Contreras
Session: Session 6 (3:00pm – 3:50pm)
Presentation Type: Poster 71
Abstract
DNA methylation, a key epigenetic mechanism, modifies gene expression without altering DNA sequences, often in response to environmental factors like stress. Chronic stress is associated with changes in DNA methylation levels in genes involved in the hypothalamic-pituitary-adrenal (HPA) axis, a key regulator of the body’s stress response. However, the interaction between cortisol, a primary stress hormone, and DNA methylation in glucocorticoid receptor genes such as NR3C1 remains poorly understood, particularly in relation to resilience mechanisms. This study examines how cumulative cortisol exposure, measured through hair cortisol analysis, correlates with DNA methylation in NR3C1, and how these changes affect gene expression and perceived stress over time. By conducting a systematic literature review and synthesizing existing research, this project identifies gaps in understanding the type of stressors influencing epigenetic modifications and their role in resilience. Additionally, this work will provide insight into cortisol-driven methylation as a potential adaptive mechanism to mitigate the effects of chronic stress. By viewing resilience as a dynamic and measurable process, this research contributes to the growing paradigm shift in resilience studies, emphasizing the molecular basis of stress adaptation. Findings aim to advance our understanding of how stress and epigenetics interact to promote resilience.
