Tyler Tsai
Research Mentor(s): Tae-Hwa Chun
Mentor Department: Internal Medicine
Authors: Tae-Hwa Chun
Session: Session 6 (3:00pm – 3:50pm)
Presentation Type: Poster 57
Abstract
Thyroid-associated orbitopathy (TAO) is a disfiguring eye disease linked to autoimmune thyroid disorders. It affects the connective tissue around the eyes, causing inflammation, fibrosis, and in severe cases, blindness. Despite its significant impact on patients, no effective treatment currently exists. Insulin-like growth factor 1 (IGF-1) is known to play a critical role in cellular signaling and metabolic regulation. Recent studies suggest a potential relationship between IGF-1 and hypoxia-inducible factor 2-alpha (HIF2A), a key regulator of hypoxic responses and tissue remodeling. However, the exact impact of IGF-1 on HIF2A expression and function remains unclear. In this study, we aimed to determine the effects of varying IGF-1 concentrations on HIF2A expression. Using a controlled experimental model, we seek to determine whether higher IGF-1 concentrations influence HIF2A expression and activation of target genes associated with extracellular matrix (ECM) remodeling. Additionally, we aim to explore whether blocking IGF-1 can decrease HIF2A levels and its downstream effects on ECM production. These findings could provide new insights into the interplay between IGF-1 and HIF2A in TAO, highlighting IGF-1 as a potential driver of hypoxia-driven processes in this disease. This study provides a foundation for developing therapeutic approaches focused on the interaction between IGF-1 and HIF2A to manage TAO.
