Investigating the role of sleep sensitive genes in GABAergic sleep neurons – UROP Spring Symposium 2025

Investigating the role of sleep sensitive genes in GABAergic sleep neurons

Yoali Banda

Research Mentor(s): Ravi Allada
Mentor Department: Anesthesiology/MNI
Authors:
Session: Session 5 (2:00pm – 2:50pm)
Presentation Type: Poster 100

Abstract

Sleep is a critical physiological process regulated by genetic and neural mechanisms, yet many aspects of its regulation remain unclear. In this study, we aim to investigate the role of sleep-sensitive genes in GABAergic sleep neurons using Drosophila as a model. We will collect virgin females expressing Gal4 in VGAT neurons and cross them with males carrying UAS-RNAi constructs, resulting in progeny with targeted gene knockdown. By knocking down individual genes, we will assess their impact on sleep duration, quality, and patterns over several days.

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