Jake Rivett
Research Mentor(s): Bing Ye
Mentor Department: Life Sciences Institute, University of Michigan
Authors: Ty Hergenreder
Session: Session 1 (9:00am – 9:50am)
Presentation Type: Poster 92
Abstract
Developmental disorders, including Down syndrome, are prevalent worldwide, yet the underlying molecular and cellular mechanisms, particularly those affecting the brain, remain poorly understood. This knowledge gap hinders the development of effective clinical therapies and highlights the urgent need for targeted research. To address this, our study investigates the role of the Down Syndrome Cell Adhesion Molecule (DSCAM) gene in neurogenesis using a mouse model. In this model, DSCAM expression is downregulated through selective breeding, enabling us to study its impact on neural development within the hippocampus, specifically the dentate gyrus—a key site of adult neurogenesis. Preliminary results obtained via immunohistochemistry reveal that DSCAM plays a critical role in supporting adult neurogenesis, influencing both the density and functionality of neural connections. These findings suggest that alterations in DSCAM expression may contribute to impaired neurogenesis observed in individuals with Down syndrome. By elucidating DSCAM’s role in neural development, our study provides insights into the cellular mechanisms of Down syndrome and highlights DSCAM as a potential therapeutic target for promoting neurogenesis in affected individuals. This research emphasizes the importance of understanding genetic contributions to developmental disorders, paving the way for novel therapeutic strategies. Ultimately, it aims to bridge the gap between molecular research and clinical applications, improving outcomes for individuals with Down syndrome and related conditions.
