Modeling cardiac aging with stem cell-derived cardiomyocytes carrying a mutation for advanced aging – UROP Spring Symposium 2021

Modeling cardiac aging with stem cell-derived cardiomyocytes carrying a mutation for advanced aging

Elijah Hall

Elijah Hall

Pronouns: he/him

Research Mentor(s): Andre Monteiro Da Rocha, Research Inverstigator
Research Mentor School/College/Department: Cardiology – CVC Cardiovascular Regeneration Core, Michigan Medicine
Presentation Date: Thursday, April 22, 2021
Session: Session 3 (1pm-1:50pm)
Breakout Room: Room 7
Presenter: 7

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Abstract

Using various images taken through a confocal microscope, the area of the nuclei in the heart cells of mice were measured in an effort to compare two varieties of cells. Those that were extracted from mice suffering from Hutchinson Gilford Progeria Syndrome (HGPS), a severe and rare cardiovascular disease. Comparing these two types of cells provided a better idea of the meaningful ways in which cell morphology is different in regards to the presence of HGPS. Differences reflecting statistical significance were identified between the heart cells of “healthy” mice and those afflicted with HGPS. This data collection helps build upon the foundation and overarching goal of the lab which is to model cardiac aging through the use of stem cell derived cardiomyocytes.

Authors: Elijah Hall
Research Method: Laboratory Research

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