Matthew Rochlen
Pronouns: he, him, his
Research Mentor(s): Salim Hayek
Co-Presenter:
Research Mentor School/College/Department: Internal Medicine – Cardiology / Medicine
Presentation Date: April 20
Presentation Type: Oral5
Session: Session 6 – 4:40pm – 5:30 pm
Room: Breakout room 4
Authors: Matthew Rochlen, Alexi Vasbinder, Pennelope Blakely, Elizabeth Anderson, Tonimarie Catalan, Salim Hayek
Presenter: 4
Abstract
Background: Bone marrow transplant (BMT) has been used as a curative therapy for many life-threatening cancers, non-malignant marrow disorders, and inborn errors of metabolism since the 1960’s. Currently, there are no large cohort studies capable of estimating incidence and identifying risk factors in regards CV complications post BMT. Objective: The purpose of this study is to determine the incidence and risk factors of in-hospital, short (=100 days), and long-term (>100 days) CVD complications in patients who received HSCT. Methods: This study is retrospective longitudinal cohort study of all patients who underwent HSCT at the University of Michigan in Ann Arbor from 2000 to 2019. Data was collected from medical record reviews and included demographics, clinical risk factors, electrocardiogram data, echocardiographic data, laboratory testing, and cardiovascular outcomes data. Cardiovascular disease was defined as a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, new onset or hospitalization of heart failure, new onset atrial fibrillation/flutter, or new onset sustained ventricular tachycardias. Results: In a total of 3,459 patients, 485 (14%) developed CVD over a median (IQR) follow-up of 2.6 (1.0, 6.5) years (table 1). Overall, the cohort consisted of 59.4% male, 90.3%white, an average age of 53.3, and average BMI of 29. Preliminary findings show compared to patients without a CV event, patients with a CV event were older, more likely to be male, have higher BMIs and systolic blood pressure, and a greater proportion of comorbidities including hypertension, diabetes, chronic kidney disease, and coronary artery disease. Conclusions: Patients who developed cardiovascular disease had a greater burden of cardiovascular risk factors. Future analyses will develop a risk prediction model to reliably stratify high-risk HSCT patients. Findings from this study will inform much-needed pre-transplantation guidelines for clinicians.
Biomedical Sciencs
