Brevin Buchman
Pronouns: he/his
Research Mentor(s): Steven Kasten
Co-Presenter:
Research Mentor School/College/Department: Surgery / Medicine
Presentation Date: April 20
Presentation Type: Poster
Session: Session 6 – 4:40pm – 5:30 pm
Room: League Ballroom
Authors: Brevin Buchman, Noah Nelson , Steven Kasten
Presenter: 35
Abstract
Deferoxamine nanoparticle is a device that intends to be accepted both as an FDA approved and clinical method of treatment for radiation induced injuries and particular use in cancer resection operations. Although there is not enough data to support efficacy in radiation induced injury, research in non-vascularized bone grafts continue to show promising positive results. The purpose of this study is to evaluate if the hyaluronic acid (HA-DFO) conjugated novel micro particle can reduce radiation induced injury that plagues non-vascularized bone grafts post radiation therapy (XRT). If this study has promising results in the density of bone and biomechanical strength, it will present a less complicated method of cancer resection in the mandible compared to the standard practice of vascularized free tissue transfer of osteocutaneous flaps. In order to test the efficacy of this implantable micro particle, male isogenic lewis rats will be split into four different testing groups. These groups include: bone graft donor (5mm iliac crest bone), control bone graft, radiated bone graft, and radiated bone graft with HA-DFO. Segmental osteotomy of mandible used a 5mm iliac crest bone by bone graft donor used in surgery. The two radiated groups underwent radiation therapy (XRT) 14 days prior to surgery. For the HA-DFO group, the device implantation is done during surgery at bone graft site. After testing, a set 60 day period for healing of injuries will be used before dissection and analysis of bony unions, their bony union rates, and biomechanical testing (BMT) on a servo-hydraulic load cell until the bones break. Although findings aren’t conclusive yet to promote efficacy of the micro particle, data is trending in a positive manner for those who wish for a more effective treatment of radiation induced injury.
Biomedical Sciences, Natural/Life Sciences
