Investigating the role of macrophages and melanocytes in basal cell carcinoma – UROP Spring Symposium 2022

Investigating the role of macrophages and melanocytes in basal cell carcinoma

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Emma Sortor

Pronouns: she/her

Research Mentor(s): Elisabeth Pedersen
Co-Presenter:
Research Mentor School/College/Department: Dermatology / Medicine
Presentation Date: April 20
Presentation Type: Poster
Session: Session 2 – 11am – 11:50am
Room: League Ballroom
Authors:
Presenter: 49

Abstract

We designed a mouse model that expresses the K5Gli2 transgene to induce basal cell carcinoma. Activating the hedgehog pathway signaling has led to an increase in nearby melanocytes, likely caused by increased Wnt ligands secreted by the tumor. We hypothesize that an increase in melanocytes correlates to an increase in macrophages which clean up the melanin pigment and potentially suppress tumor development.

Presentation link

Biomedical Sciences, Interdisciplinary

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