Seth Woodbury
Pronouns: He/Him/His
Research Mentor(s): Yuji Mishina
Co-Presenter:
Research Mentor School/College/Department: Biological and Material Sciences / Dentistry
Presentation Date: April 20
Presentation Type: Oral10RS
Session: Session 5 – 3:40pm – 4:30 pm
Room: Vandenberg
Authors: Seth Woodbury, Ben Swanson, Lindsey Douglas, Yuji Mishina
Presenter: 1
Abstract
Poly (L-lactic acid) (PLLA) is a biomaterial widely used in tissue engineering and regenerative medicine applications, particularly as a scaffolding matrix due to its safety and biocompatibility. Nanofibrous and porous scaffolds made from PLLA have been widely demonstrated to be useful in dental and craniofacial applications. Despite many advantageous properties, traditional PLLA scaffold platforms are hindered by poor clinical handling properties: they are unable to be shaped to defects without destroying favorable macro and micro features of the material. We have developed a novel tissue engineering matrix from a PLLA-based biomaterial that allows for the thermosensitive reprogramming of their macroscopic clinical shape, while maintaining micro and nano-scale features. Within this biomaterial, we have embedded a customizable, nanoparticle-conjugated drug delivery system that continuously releases drugs and/or biomolecules into the local defect over the course of a month. Our tissue engineering matrices have shown in-vitro efficacy in facilitating bone marrow-derived stem cell (BMSC) proliferation and migration throughout the matrices after 50% mechanical deformations and thermosensitive reprogramming. Future experiments will investigate the efficacy of the drug delivery system by conjugating platelet-derived growth factors (PDGF) to the embedded nanoparticles, which we predict will increase BMSC differentiation.
Biomedical Sciences
