Chloe Darancou
Pronouns: She/Her/Hers
UROP Fellowship: Biomedical and Life Sciences
Research Mentor(s): Yongqun Oliver He, PhD
Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School
Presentation Date: Tuesday, July 28, 2020 | Session 1 | Presenter: 7
Authors: Chloe Darancou, Eliyas Asfaw, Asiyah Yu Lin, Siqi Li, Anthony Huffman, Bin Zhao, Farah Reyal, Edison, Zuoshuang Xiang, Yongqun He
Abstract
Cancer is the second leading cause of death in the United States and has become a global public health problem. Cancer is the abnormal or uncontrolled growth of cells in the body caused by mutations of DNA within cells. In many cases cancer is characterized by the growth of a tumor within the body; however, in cancers such as Leukemias, a tumor is not always present. In recent years, there have been extensive studies experimenting with the concept of cancer vaccines. Cancer vaccines can either be used to prevent or treat cancer through injection of antigens or cancer cells, in order to stimulate an immune response in a patient. One of the more commonly known cancer vaccines is the HPV vaccine which is used to prevent the infection of HPV, thus preventing the cancers associated with the infection of the virus. The primary goal in this project is to compile a database, CanVaxKB, that lists cancer vaccines that have been tested or are currently being tested, in order to expand the spread of information regarding these vaccines and cancer research as a whole. CanVaxKB includes information regarding the genes of the antigens/cells presented in the vaccine while discussing clinical trials associated with each vaccine. This database allows for thorough explanation into treatments for a certain type of cancer by enabling a user to compare two or more vaccines. Furthermore, from this database and compilation of vaccines we are able to utilize ontology and discover relationships and commonalities between cancer vaccines to further our understanding and research.
Google Slide Presentation
Presentation Script
Research Disciplines
Biomedical Sciences, Interdisciplinary, Natural Sciences, Life Sciences
