Elijah Paparella
Pronouns: He/Him/His
UROP Fellowship: Biomedical and Life Sciences
Research Mentor(s): Megan Killian, PhD
Department of Orthopaedic Surgery
Presentation Date: Monday, July 27, 2020 | Session 2 | Presenter: 5
Authors: Elijah Paparella, Connor C. Leek, and Megan Killian, Ph.D.
Abstract
Bone superstructures are protrusions of various shapes and sizes which act as stable attachment sites for tendons and dissipate localized mechanical loads at the interface between muscle and bone. Recent studies have shown that these superstructures initiate during embryonic development from cellular signaling of a progenitor pool of cells and continue to grow during perinatal development in response to mechanical loading. The purpose of my research is to investigate how two novel genetic modifications in mice influence the size and shape of superstructures on long bones. To do this, I developed a method to quantitatively analyze the volume and length of superstructures using three-dimensional bioimaging tools, such as Dragonfly. This phenotyping approach using archival micro-computed tomography data of transgenic mouse strains developed in our laboratory will inform our next steps for in-depth histological and cellular studies of superstructure development that are dependent on genetic modifications.
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Research Disciplines
Biomedical Sciences
