Daniel Kim
Research Mentor(s): Angelo Anacleto
Mentor Department: MIP
Authors: Daniel Kim, Angelo Anacleto
Session: Session 1 (9:00am – 9:50am)
Presentation Type: Poster 3
Abstract
In the modern society, preservation of organic functions is a major health concern for the elderly population. Dysregulation of tissue homeostasis are associated with organ frailty and disease progression, where the regenerative units such as the adult stem cells and neighboring niche cells relate them. To better understand how age affects the weakening of regenerative functions, finding out how age affects niche cell types and expressions (mRNA) to understand regenerative remedial approaches. To understand molecular mechanism of reverse age-related disorders, niches in young, old, and regenerated tissues can be spatial profiled using Ex-Scope (integration of Expansion Microscopy and Seq-Scope). The spatial transcriptomic technology allows the user to obtain high resolution of the multi-Omics method and helps to spatially profile planarians tissues. Planarians are flatworms that are most noted for their capability to regenerate any lost body parts with youthful tissue architecture. This trait makes them ideal for tissue homeostasis and rejuvenation. By studying its mRNA single cell data, it can spatially provide an insight into how planarians’ niche and stem cells perform their rejuvenation.
