James Lyman III
Pronouns: he/him
Research Mentor(s): Youngsoo Kim
Co-Presenter:
Research Mentor School/College/Department: Chemistry / LSA
Presentation Date: April 20
Presentation Type: Poster
Session: Session 3 – 1:40pm – 2:30 pm
Room: League Ballroom
Authors:
Presenter: 120
Abstract
In our work in the Kennedy Lab, we aim to further understand the connection between neurochemical concentrations of the basal forebrain, the development of REM sleep behavior disorder, and the connection of both to the development of Parkinson’s disease. To do so, samples were taken in-vivo from rodent basal forebrains using microdialysis. Six specific neurochemicals were selected to compare in concentrations over time: taurine, serine, glutamine, phenylalanine, glucose and adenosine. With the use of Liquid Chromatography & Mass Spectrometry (LCMS) the Kennedy Lab aims to determine the neurochemicals associated with sleep and wakefulness. With the relationship between adenosine and sleep deprivation being better understood from prior research, adenosine provides a point of reference to compare and contrast the other neurochemicals with. By investigating the correlation between sleep deprivation and concentrations, we aim to better understand the neurochemical mechanism of sleep and wakefulness. Since current research suggests REM sleep behavior disorder may be a prodromal marker of Parkinson’s disease, future research built off the findings of this project may link the neurochemistry of sleep and wakefulness with the development of Parkinson’s disease.
Natural/Life Sciences
