Elucidating the Physiological function of human B12 trafficking protein CblD – UROP Summer Symposium 2021

Elucidating the Physiological function of human B12 trafficking protein CblD

Nia Jones

Nia Jones

Pronouns: She/Her/Hers

UROP Fellowship: Biomedical and Life Sciences
Research Mentor(s): Ruma Banerjee, PhD and Zhu Li, PhD
Research Mentor Institution/Department: Michigan Medicine, Department of Biological Chemistry

Presentation Date: Wednesday, August 4th
Session: Session 1 (3pm-3:50pm EDT)
Breakout Room: Room 2
Presenter: 3

Event Link

Abstract

Mutations in the mmadhc gene are responsible for the cblD-type defect in vitamin B12 metabolism. To better understand the role of the CblD chaperone protein in the B12-trafficking pathway, we propose to transfect human cells with expression vectors for epitope-tagged wild-type or mutant CblD to study how patient mutations impact localization and affects B12 metabolism. My short-term goal has been to generate the expression vectors and help establish the cytoplasmic versus mitochondrial localization of CblD.

Authors: Nia Jones, Zhu Li, Ruma Banerjee

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