Engineering – UROP Summer Symposium 2021

Engineering

Ontological Vaccine Adjuvant Knowledge Presentation and Application in Adjuvant Design for Vaccine Development

Many adjuvants (substances that increase immune response) are used in vaccine development. Some of their mechanisms have been studied extensively, others unknown. One challenge is how to collect and logically represent them so patterns can be identified and AI ready. Another challenge is how to use the patterns and information for machine learning.

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Lasers: Optical Tweezers for Medicine

Using laser beams as a means of manipulating and trapping particles on the nanoscale has been proven extremely beneficial to the fields of chemistry and biology. These “optical tweezers” are highly useful for their non-invasiveness and precise delivery of nano-objects such as metal nanoparticles. In this study, we will optimize a two phase ligand exchange process to develop stable metal nanoparticles. This two phase ligand exchange technique is a reliable and relatively straightforward method of producing stable metal nanoparticles capable of being used in a variety of biological applications.

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Lasers: Optical Tweezers for Medicine

Using laser beams as a means of manipulating and trapping particles on the nanoscale has been proven extremely beneficial to the fields of chemistry and biology. These “optical tweezers” are highly useful for their non-invasiveness and precise delivery of nano-objects such as metal nanoparticles. In this study, we will optimize a two phase ligand exchange process to develop stable metal nanoparticles. This two phase ligand exchange technique is a reliable and relatively straightforward method of producing stable metal nanoparticles capable of being used in a variety of biological applications.

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African Futurist Greenhouse

Colonialism may be in the past, but its legacies live on today, with populations still marginalized by income and still “primitivized” by the colonial view. New movements like AfroFuturism resist these stereotypes by combining technological sophistication with an anti-primitivist view of Black culture. In the book African Fractals, Dr. Eglash makes the case for scaling geometries–the nonlinear shapes found in nature–as a tradition in African design. Together with professor Audrey Bennett at UM’s Stamps School of Art and Design, and Olayami Dabls, the owner of Dabls’ MBAD African Bead Museum, they have developed a proposal to create an African Futurist greenhouse that will utilize the scaling geometry traditional to African homes, jewelry, and sculptures. Funded by Stamps and Poverty Solutions, this greenhouse will grow plants that furnish seeds for Dabls’s beadwork, food for local consumption, and more generally embody a decolonial approach that combines the circular economy of Indigenous traditions with the beauty and utility of culture-technology hybrids.

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African Futurist Greenhouse

Colonialism may be in the past, but its legacies live on today, with populations still marginalized by income and still “primitivized” by the colonial view. New movements like AfroFuturism resist these stereotypes by combining technological sophistication with an anti-primitivist view of Black culture. In the book African Fractals, Dr. Eglash makes the case for scaling geometries–the nonlinear shapes found in nature–as a tradition in African design. Together with professor Audrey Bennett at UM’s Stamps School of Art and Design, and Olayami Dabls, the owner of Dabls’ MBAD African Bead Museum, they have developed a proposal to create an African Futurist greenhouse that will utilize the scaling geometry traditional to African homes, jewelry, and sculptures. Funded by Stamps and Poverty Solutions, this greenhouse will grow plants that furnish seeds for Dabls’s beadwork, food for local consumption, and more generally embody a decolonial approach that combines the circular economy of Indigenous traditions with the beauty and utility of culture-technology hybrids.

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Great Lakes Water Policy

As climate conditions worsen, natural freshwater supplies of ground and surface water are depleted for a variety of uses and water becomes an increasingly sought-after resource. Policymakers have responded to this situation with several documents that govern how water can be withdrawn, diverted, distributed, and reallocated to different basins. This research compares the strengths and weaknesses of two different water resource management agreements: the Great Lakes-St. Lawrence River Basin Water Resources Compact that governs the eight Great Lakes states and two provinces of Canada and the Sustainable Groundwater Management Act which was recently passed in California. Both documents aim to disarm future water controversies, but they deal with seemingly polarized water supply scenarios. The research brings together several different sources of information about water policy and identifies gaps between the policy and its application. The contexts and purposes of these documents hint at how they will hold up to debate in terms of environmental, economic, and social sustainability.

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The Great Lakes Compact and Water Level Variability

The Great Lakes Compact is an agreement guiding water management of the Great Lakes. The Compact has been signed and approved by the governors of the eight states within the Great Lakes basin (Wisconsin, Illinois, Indiana, Michigan, Minnesota, New York, Ohio and Pennsylvania) and the two Canadian provinces within the Great Lake basin (Ontario and Quebec). The Compact was signed into law by President George W.Bush in 2008. The Great lakes play a significant role in the regional economy and support recreation, and wildlife habitat and a balanced ecosystem of the environment.

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Design of a Do-It-Yourself Geiger-Muller counter with smartphone mapping application

A Geiger-Muller survey meter is a device for measuring radioactivity by detecting and counting ionizing particles. Antique Geiger-Muller (GM) survey meters recovered from fallout shelters were gifted to teachers by several nuclear scientific societies to demonstrate radiological principles. Although these GMs accomplish some educational objectives, they fail to engage students with modern technology to motivate nuclear careers, develop students’ electronic or software skills, or provide individuals with a more hands-on approach when it comes to exploring radiological sciences. This is why the Do-It-Yourself Geiger-Muller (DIYgm) project was created. This project has as its objective to expose students to STEM topics such as computer programming, circuit-building, and soldering, while maintaining a special emphasis on radiological and nuclear science disciplines.

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Ontological Representation and Machine Learning Prediction of Drugs for COVID-19 Treatment

Background: SARS-CoV-2 is a human coronavirus that has caused COVID-19 and is able to rapidly mutate and spread throughout the world. While the usage of COVID-19 vaccines has drastically reduced illness, new variants of the virus continue to show up and reduce vaccination efficiency. Given the continuous spreading of the disease, effective drugs for treating COVID-19 are urgently needed; however, very effective drugs for COVID-19 have not yet been approved for public use. Drug repurposing is a strategy to discover new uses for thousands of approved drugs previously used for other illnesses. It is possible to use the drug repurposing strategy to find drugs for effective COVID-19 treatment. This study aims to analyze drugs and their effects on the human body to further predict effective drugs for COVID-19 using machine learning algorithms.

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2021 Powertrain Strategies for the 21st Century

My Research Project pertains to Powertrain Strategies for the 21st Century survey project of the Automotive Futures Group. This survey of automotive industry experts including manufacturers, suppliers, government, NGOs, academia, and consultants looks to forecast the percentage of different powertrains that will be sold in 2025 and 2030 as well as asking experts about their expectations for the Biden Administrations CAFÉ regulations impacts, how will the industry use its credits to meet their goals, will manufacturers be able to meet aggressive state goals for eliminating gas fueled vehicle sales, and how will the auto industry make the transition to EVs, including questions on charging infrastructure. Our analyses will address these questions and report differences, if any, among the three groups of respondents (manufacturers, suppliers, and the group of government, NGOs, academia, and consultants). A unique characteristic of our analyses will be our weighting of responses by the confidence respondents report about their answers. Our results will be a continuation of this survey that dates back to 2007 that has tracked powertrain expert responses to the future of powertrains in the US.

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