Health Sciences – Page 2 – UROP Summer Symposium 2021

Health Sciences

The mechanistic basis of anti-CD6 as a novel form for the treatment of autoimmune diseases and cancer

Background: The use of Immune Checkpoint Inhibitors (ICIs) is limited by the induction of immune-related adverse events. CD6 is expressed by most T lymphocytes and a subset of natural killer (NK) cells, and engages the ligands CD166/ALCAM and CD318. Interrupting CD6 interaction with its ligands using UMCD6 (anti-CD6) reverses autoimmunity in mouse models of rheumatoid arthritis, multiple sclerosis and uveitis, due to suppression of differentiation of effector Th1 and Th17 cells. Recently, we have demonstrated that UMCD6 directly activates CD8+T and NK cells, enhancing these cells to kill breast, lung, and prostate cancer lines, even more robustly than ICIs directed to the PD-1/PD-1L pathway. We now explore the mechanisms by which UMCD6 activates NK cells while controlling the differentiation of CD4 cells.

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Evaluation of Myelinating Schwann Cells in CHARGE Syndrome

CHARGE Syndrome is a multiple malformation condition that is characterized by congenital abnormalities including coloboma of the eye, heart defects, atresia choanae, retardation of growth, genital abnormalities, and ear abnormalities. A hallmark feature of CHARGE is ear abnormalities which manifest as conductive and sensorineural hearing loss and balance disorders. The primary cause of CHARGE is pathogenic variants in the gene CHD7 (Chromodomain Helicase DNA binding protein 7), which encodes an ATP-dependent chromatin remodeling protein. Loss of Chd7 disrupts development of the neural crest, a transient migratory cell population that gives rise to a variety of cell types including sensory neurons and myelinating Schwann cells of the inner ear. Given that proper myelination is essential for peripheral auditory system function, we hypothesized that pathogenic variants in CHD7 disrupt sensory neurons and myelinating Schwann cells in the cochlear spiral ganglion.

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Experiences of side effects due to COVID-19 vaccination among rheumatic disease patients: a qualitative analysis.

Background: Although rheumatic and musculoskeletal diseases (RMDs) are fairly common, individuals with RMDs were not included in the randomized control trials for COVID-19 vaccines, resulting in a lack of knowledge about the possible side effects they may face. Side effects may play a role in whether or not members of this population want to receive the COVID-19 vaccine and may highlight differences in vaccine response between these individuals and the general population. We aimed to describe patients’ self-reported experiences of side effects and other treatment burdens related to COVID-19 vaccination.

Experiences of side effects due to COVID-19 vaccination among rheumatic disease patients: a qualitative analysis. Read More »

A mobile contraceptive decision support tool for people with health conditions: A pilot feasibility study in primary care (The My Health, My Choice Study)

Background: Finding the right birth control can be difficult. It can be especially challenging for people with chronic conditions who may have contraindications to hormonal methods and disease-specific concerns related to reproductive health and contraception. Aims: 1) To assess the feasibility and acceptability of a novel mobile contraceptive decision tool (My Health, My Choice); 2) to explore associations between use of My Health My Choice and contraceptive use, contraceptive satisfaction, person-centered contraceptive counseling, and contraceptive self-efficacy.

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Binge Drinking Behaviors Among Sexual Minority Youth

Sexual minority youth (SMY), defined as youth who are not heterosexual or cis gendered, disproportionately engage in alcohol use behaviors, namely binge drinking, current alcohol use, and younger age of first consumption. Despite these disparities, research focused on alcohol use behaviors among SMY is limited. Because alcohol consumption is linked to sexual and other risk behaviors, there is a critical need to expand on this body of research to inform the development of interventions to decrease alcohol use behaviors among SMY. The purpose of this study was to explore whether SMY are more likely to report binge drinking than sexual majority groups in Michigan.

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The Effect of Prosthetic Leg Length on Low Back Muscle Activity and Pain during Walking and Sit-to-Stand

People with lower limb amputation have a greater incidence of low back pain than the general population, with some estimates as high as 65%. One potential cause of pain in this population is leg length asymmetry as it can lead to altered trunk-pelvis movement, and subsequently altered low-back loading. The purpose of this study was to determine the effect of changes in prosthetic leg length on low back muscle activity and self-reported low-back pain.

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Analyzing Readability of COVID-19 Biomedical Literature

Reading scientific literature such as preprints and papers is different from reading ordinary English novels. The average American reads at the 7th- to 8th-grade level, according to the Literacy Project [1]. The COVID-19 pandemic is unique in a way that not only scientists but also the general public actively seek for scientific information that would help to understand the new viral infection and fight its spread. The COVID-19 related literature has been read by the public, government officials, and people who had no prior biomedical education but it is questionable how much was understood. The goal of this project is to understand how readable the COVID-19 biomedical articles are and whether they could be easily understood by an average American.

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MATLAB Programming for Data Packaging

Research is being conducted within the University of Michigan Direct Brain Interface (UM-DBI) Laboratory to develop an option for people with physical impairments to access communication devices without physical movement through brain-computer interfaces (BCIs). Currently, the majority of the BCI data from the laboratory is stored in a BCI2000 file format which is raw data and cannot be edited or modified after it is obtained. The MATLAB Programming for Data Packaging Project focuses on improving the data storing and editing process for a custom Data Packaging Graphical User Interface (GUI) within MATLAB.

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Apoptotic Effect of Deoxycholic Acid and Ursodeoxycholic Acid on Human Colon Cancer Cells

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Current treatments for colorectal cancer include surgery, radiation, and chemotherapy; however, the five-year survival rate for distant CRC is 16%. Due to the ineffectiveness of standard treatments, especially at distant CRC, new therapeutics are needed to provide more effective treatment options at all stages.

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