UROP Fellowship: Biomedical and Life Sciences
Research Mentor(s): Somin Lee, PhD
Research Mentor Institution/Department: College of Engineering, Department of Electrical and Computer Engineering
Presentation Date: Wednesday, August 4th
Session: Session 3 (5pm-6:20pm EDT)
Breakout Room: Room 1
The APP (amyloid precursor protein) is particularly relevant in the investigation of neurodegenerative diseases, notably Alzheimer’s, as a result of rare mutations in APP protein coding gene. Quantifying cell mRNA levels is crucial to the determination of cell genomic status: mRNA is transcribed from cell DNA, and ultimately translated to cell proteins. In this project, we will administer the CRISPR/Cas9 complex in neuroblastoma cells, and confirm the alteration of APP gene expression.